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Methaqualone is usually a hypnotic sedative. It was offered underneath the brand name names Quaalude (/ˈkweɪluːd/ KWAY-lood) and Sopor amongst Other people, which contained three hundred mg of methaqualone, and sold as a mix drug underneath the model title Mandrax, which contained 250 mg methaqualone and twenty five mg diphenhydramine in the exact pill, mostly in Europe.

As of now, quaaludes are usually not lawfully developed or out there in the majority of nations around the world. The initial formulation of methaqualone-dependent quaaludes is now not created, and they are classified as controlled substances in lots of destinations due to their probable for abuse and adverse wellness consequences.

As opposed to most benzodiazepines, methaqualone functions as being a detrimental allosteric modulator at a number of GABA-A receptor subtypes, which tends to bring about an excitatory response in neurons expressing People receptors. Mainly because methaqualone is often possibly excitatory or inhibitory according to the subunit composition on the GABA-A receptor, it may be characterized as a mixed GABA-A receptor modulator.[7] The methaqualone binding web page is unique from your benzodiazepine, barbiturate, and neurosteroid binding websites within the GABA-A receptor sophisticated, and it might partly overlap Along with the etomidate binding web-site.[7]

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The improve in its lawful standing greatly impacted how usually Medical practitioners prescribed the drug. But certainly, the availability and desire of ludes didn’t go away.

Unlawful initiatives to weaponize methaqualone have occurred. In the eighties, the apartheid regime in South Africa requested the covert manufacture of a large amount of methaqualone at the entrance corporation Delta G Scientific Firm, as Section of a solution chemical weapons system often known as Undertaking Coastline.

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